What game to try next? Suggestions?

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I am finishing my 2nd game of midlife cluster, medium size galaxy, medium AI just to figure the game out.

For my next game I want to try midlife cluster, large galaxy, High AI.

Am I going to get pounded with so little experience? What can I add to make it interesting. I was thinking about making some of the races religious, psychic, organic, etc.

I am not ready to use mods or import AI's, just trying to stick to the stock things I can modify when creating a game.